Opioid-Induced Hyperalgesia (OIH)

Opioid-induced hyperalgesia (OIH).

BACKGROUND AND OBJECTIVES Opioids are commonly used for pain control; however, they can cause hyperalgesia. The reason why this can happen is not known. The objective of this review was to describe the mechanisms, factors implicated, and drug modulation. CONTENTS The factors implicated in the development of opioid-induced hyperalgesia (OIH), such as duration of use, dose, and type of opioids ...

Opioid-induced hyperalgesia (OIH): a real clinical problem or just an experimental phenomenon?

Although opioid-induced hyperalgesia (OIH) is mentioned as a potential cause of opioid dose escalation without adequate analgesia, true evidence in support of this notion is relatively limited. Most studies conducted in the context of acute and experimental pain, which seemingly demonstrated evidence for OIH, actually might have measured other phenomena such as acute opioid withdrawal or tolera...

Opioid Induced Hyperalgesia

Opioid Induced Hyperalgesia

Opioid Induced Hyperalgesia

Introduction Pain is one of the main reasons that people seek medical attention, and it is estimated to affect tens of millions of Americans. Chronic pain management commonly includes the use of opioid type medications. This is in spite of that fact that this class of drugs has well known adverse effects including the development of dependence, tolerance, and addiction. Recently, however, a tro...